Medicated chewing gums are solid, single-dose preparations that have to be chewed and not swallowed; chewing gums contain one or more active ingredients that are released by chewing. Drug absorbed directly, via the buccal membrane, avoids metabolism in the gastrointestinal tract and the first-pass effect of the liver. It might therefore be possible to administer a reduced dose in chewing gum compared to other oral delivery systems. In the present study six sets of coating formulations were prepared and studied. The coating solution was applied on uncoated chewing gum for six batches. Each coating on chewing gum was based on weight of uncoated chewing gum. This was applied in range of 40, 44, 48, 52, 56 and 60% with respect to weight of uncoated chewing gum. The dissolution curve for release of dichlorobenzyl alcohol and amylmetacresol for all six batches (AB1 to AB6) were compared. The drug release kinetics was calculated by dissolution curve. Formulation AB1 showed lowest drug release of 75.83% at the end of 30 minutes and formulation AB6 showed highest drug release of 91.72% at the end of 30 minutes. The formulation with lowest sensory determination was AB1 with acceptance of 40% and the formulation with highest sensory determination was AB6 with acceptance of 90%. As the concentration of the coating solution is increased in the coating formulation, the crunchiness was increased. It can be said that with varying the concentration of coating solution in the formulation, the crunchiness can be controlled.
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